Article
Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men.
Environmental health and preventive medicine - 1 May 2016
Hashimoto Marowa, Watanabe Masutaka, Uematsu Yuji, Hattori Sonomi, Miyai Nobuyuki, Utsumi Miyoko, Oka Mayumi, Hayashida Mariko, Kinoshita Kenji, Arita Mikio, Takeshita Tatsuya
Abstract excerpt
OBJECTIVES: Many East Asians have the genetic polymorphisms rs1229984 in alcohol dehydrogenase 1B (ADH1B) and rs671 in aldehyde dehydrogenase 2 (ALDH2). Here we analyzed the relationships of the two genotypes with alcohol sensitivity, drinking behavior and problem drinking among older and younger men living in rural areas of Japan. METHODS: The subjects were 718 Japanese men aged 63.3 ± 10.8 (mean ± SD),...
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