Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men.

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Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2003

Yokoyama Tetsuji, Yokoyama Akira, Kato Hoichi, Tsujinaka Toshimasa, Muto Manabu, Omori Tai, Haneda Tatsumasa, Kumagai Yoshiya, Igaki Hiroyasu, Yokoyama Masako, Watanabe Hiroshi, Yoshimizu Haruko

Abstract excerpt

Alcohol flushing after light drinking is triggered mainly by severe acetaldehydemia in individuals possessing inactive aldehyde dehydrogenase (ALDH)-2. Inactive ALDH2 encoded by ALDH2*1/2*2 and the low-activity form of alcohol dehydrogenase (ADH)-2 encoded by ADH2*1/2*1 enhance the risk for esophageal cancer in Japanese light to heavy drinkers, a significant association that emphasizes the importance of screening...

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PMID: 14652286

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ALDH2

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