Article
Association of the polymorphisms rs179008 (TLR7), rs2004640 (IRF5), rs1800795 (IL-6) and rs2280788 (CCL5) with systemic lupus erythematosus in women of Mayan ethnicity from Yucatan.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2024
Nakazawa-Ueji Yumi Elena, Valencia-Pacheco Guillermo, González-Herrera Lizbeth Josefina, Chan-Chalé Laureano, Velasco-Cárdenas Rubí Misol-Ha, Carreño-Gonzalez Martha Julia, Pérez-Mendoza Gerardo, Amaro-Adrián Guadalupe Isabel, Rodríguez-Dzul Edwin Arturo, Quintal-Ortiz Irma Guadalupe, Angulo-Ramírez Angélica Vanesa, López-Villanueva Ricardo Francisco
Abstract excerpt
Introduction: IFN-α is the main cytokine in SLE, and single nucleotide polymorphisms (SNP) in different genes could induce it. Aim: To determine the association of rs2004640 (IRF5), rs179008 (TLR7), rs1800795 (IL-6) and rs2280788 (CCL5) with SLE in Mexican women with Mayan ethnicity. Methods: DNA and RNA were isolated from the peripheral blood of 110 patients and 200 healthy control subjects. SNP genotyping and...