Structural basis for T-cell receptor recognition of p53Y220D, a human cancer neoantigen.

Abstract excerpt

Adoptive cell therapy (ACT) with tumor-specific T cells can mediate durable cancer regression. The main target of tumor-specific T cells are neoantigens resulting from mutations in self-antigens over the course of malignant transformation. To understand T-cell recognition of cancer neoantigens at the atomic level, we studied a T-cell receptor (TCR 4414A) that recognizes a neoepitope arising from a driver mutation...

Topics

• Humans
• Tumor Suppressor Protein p53
• Receptors, Antigen, T-Cell
• Crystallography, X-Ray
• HLA-A2 Antigen
• Antigens, Neoplasm