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Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of adults with tuberculosis infection and disease

7 Mar 2024

Abstract excerpt

Objectives To investigate whether Mycobacterium tuberculosis (Mtb) DNA is detected in peripheral blood mononuclear cells (PBMC) of subjects with tuberculosis (TB) or TB infection (TBI) living in a low TB burden country. Methods We prospectively enrolled 57 TB-patients, 41 TBI-subjects and 39 controls in Rome, Italy. PBMC were isolated, CD34 + and CD34 − cells were immunomagnetic separated, DNA was extracted and...

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PMID: 38458427
DOI: 10.1016/j.ijid.2024.106999

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