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A more reliable PCR for detection of Mycobacterium tuberculosis in clinical samples

1 Mar 1994

Abstract excerpt

Diagnostic techniques based on PCR have two major problems: false-positive reactions due to contamination with DNA fragments from previous PCRs (amplicons) and false-negative reactions caused by inhibitors that interfere with the PCR. We have improved our previously reported PCR based on the amplification of a fragment of the Mycobacterium tuberculosis complex-specific insertion element IS6110 with respect to...

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Identifiers

PMID: 8195377
DOI: 10.1128/jcm.32.3.672-678.1994

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