Article
FUT2 genetic variants as predictors of tumor development with hepatocellular carcinoma.
International journal of medical sciences - 1 Jan 2017
Chen Chih Tien, Liao Wen Ying, Hsu Chia Chun, Hsueh Kuan Chun, Yang Shun Fa, Teng Ying Hock, Yu Yung Luen
Abstract excerpt
Lewis antigens related to the ABO blood group are fucosylated oligosaccharides and are synthesized by specific glycosyltransferases (FUTs). FUTs are involved in various biological processes including cell adhesion and tumor progression. The fucosyltransferase-2 gene (FUT2) encodes alpha (1,2) fucosyltransferase, which is responsible for the addition of the alpha (1,2)-linkage of fucose to glycans. Aberrant...
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