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Article

Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.

Brain : a journal of neurology - 3 Oct 2024

He Jun, Cabrera-Mendoza Brenda, De Angelis Flavio, Pathak Gita A, Koller Dora, Curhan Sharon G, Curhan Gary C, Mecca Adam P, van Dyck Christopher H, Polimanti Renato

Abstract excerpt

Hearing difficulty (HD) is a major health burden in older adults. While ageing-related changes in the peripheral auditory system play an important role, genetic variation associated with brain structure and function could also be involved in HD predisposition. We analysed a large-scale HD genome-wide association study (GWAS; ntotal = 501 825, 56% females) and GWAS data related to 3935 brain imaging-derived...

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Identifiers

PMID: 38454550
DOI: 10.1093/brain/awae077
PMCID: PMC11449129

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