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Article

New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis

7 Mar 2024

Abstract excerpt

The regulatory mechanism of gonadal sex differentiation, which is complex and regulated by multiple factors, remains poorly understood in teleosts. Recently, we have shown that compromised androgen and estrogen synthesis with increased progestin leads to all-male differentiation with proper testis development and spermatogenesis in cytochrome P450 17a1 (cyp17a1)-/- zebrafish. In the present study, the phenotypes...

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PMID: 38451917
DOI: 10.1371/journal.pgen.1011170

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