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Article

Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis.

PLoS genetics - 22 Jul 2010

Rodríguez-Marí Adriana, Cañestro Cristian, Bremiller Ruth A, Nguyen-Johnson Alexandria, Asakawa Kazuhide, Kawakami Koichi, Postlethwait John H

Abstract excerpt

The molecular genetic mechanisms of sex determination are not known for most vertebrates, including zebrafish. We identified a mutation in the zebrafish fancl gene that causes homozygous mutants to develop as fertile males due to female-to-male sex reversal. Fancl is a member of the Fanconi Anemia/BRCA DNA repair pathway. Experiments showed that zebrafish fancl was expressed in developing germ cells in...

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Identifiers

PMID: 20661450
DOI: 10.1371/journal.pgen.1001034
PMCID: PMC2908690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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