Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish.

Endocrinology - 1 Oct 2018

Zhai Gang, Shu Tingting, Xia Yuguo, Lu Yao, Shang Guohui, Jin Xia, He Jiangyan, Nie Pin, Yin Zhan

Abstract excerpt

Cytochrome P450 (Cyp)17A1 has both 17α-hydroxylase and 17,20-lyase activities, which are involved in the steroidogenic pathway that produces androgens and estrogens. Previously, a phenotype of all-male cyp17a1-deficient zebrafish generated by transcription activatorlike effector nuclease has been reported. In the current study, the mechanisms relating to Cyp17a1 that are involved in the development of sexual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogens
Share to Follicle Stimulating Hormone
Share to Ovary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sex Differentiation

Share to Sexual Development

Share to Spermatogenesis

Share to Steroid 17-alpha-Hydroxylase

Share to Testis

Source

Identifiers

PMID: 30202919
DOI: 10.1210/en.2018-00551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish.PMID 30202919Read ↗

Cyp17a1 is Required for Female Sex Determination and Male Fertility by Regulating Sex Steroid Biosynthesis in FishSemantic proximity Read ↗

Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiationSemantic proximity Read ↗

Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.Semantic proximity Read ↗

Estrogen Signaling Inhibits the Expression of anti-Müllerian hormone (amh) and gonadal-soma-derived factor (gsdf) during the Critical Time of Sexual Fate Determination in ZebrafishSemantic proximity Read ↗

Targeted Disruption of Aromatase Reveals Dual Functions of cyp19a1a During Sex Differentiation in Zebrafish.Semantic proximity Read ↗

Characterization of the Interrenal Gland and Sexual Traits Development in cyp17a2-Deficient ZebrafishSemantic proximity Read ↗

New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesisSemantic proximity Read ↗

Mutation ofcyp19a1bresults in sterile males due to efferent duct obstruction in Nile tilapiaSemantic proximity Read ↗

Cyp11a2 Is Essential for Oocyte Development and Spermatogonial Stem Cell Differentiation in Zebrafish.Semantic proximity Read ↗

Fertility impairment with defective spermatogenesis and steroidogenesis in male zebrafish lacking androgen receptor†Semantic proximity Read ↗

Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish - a novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis.Semantic proximity Read ↗

dmrt1 Is Responsible for Androgen-Induced Masculinization in Nile Tilapia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.