Article
Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.
Genes - 30 May 2022
Khanal Praval, Morse Christopher I, He Lingxiao, Herbert Adam J, Onambélé-Pearson Gladys L, Degens Hans, Thomis Martine, Williams Alun G, Stebbings Georgina K
Abstract excerpt
Background: Heritability explains 45-82% of muscle mass and strength variation, yet polygenic models for muscle phenotypes in older women are scarce. Therefore, the objective of the present study was to (1) assess if total genotype predisposition score (GPSTOTAL) for a set of polymorphisms differed between older women with low and high muscle mass, and (2) utilise a data-driven GPS (GPSDD) to predict the variance...
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