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Article

Genetic predisposition to hand grip strength predicts cognitive decline.

Neurobiology of aging - 1 Aug 2026

Bercovitch Rachel, Tio Earvin S, Wickramatunga Rajith, Misztal Melissa, Gicas Kristina, De Jager Philip L, Schneider Julie A, Buchman Aron S, Bennett David A, Rajji Tarek, Kennedy James L, Felsky Daniel

Abstract excerpt

Hand grip strength (HGS) is a predictor of cognitive decline in aging. To understand the direct and indirect mechanisms underlying this association, we performed integrative analyses of genetic, cognitive, and autopsy data. A polygenic risk score for HGS (PRSHGS) was calculated in two independent studies of aging (total n = 25,227). Cross-sectional and longitudinal modeling, including mediation with physical...

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Identifiers

PMID: 41955736
DOI: 10.1016/j.neurobiolaging.2026.02.008

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HGS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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