Article
Human plasma proteomic profile of clonal hematopoiesis.
Nature communications - 27 Nov 2025
Yu Zhi, Vromman Amélie, Nguyen Ngoc Quynh H, Schuermans Art, Li Linke, Rentz Thiago, Nakao Tetsushi, Vellarikkal Shamsudheen K, Uddin Md Mesbah, Niroula Abhishek, Griffin Gabriel, Honigberg Michael C, Lin Amy E, Gibson Christopher J, Katz Daniel H, Tahir Usman A, Fang Shi, Dron Jacqueline S, Pan Michael, Haidermota Sara, Ganesh Shriienidhie, Antoine Tajmara, Weinstock Joshua, Austin Thomas R, Vasan Ramachandran S, Peloso Gina M, Hornsby Whitney, Ganz Peter, Manson JoAnn E, Haring Bernhard, Kooperberg Charles, Reiner Alexander P, Bis Joshua C, Psaty Bruce M, Min Yuan-I, Correa Adolfo, Lange Leslie A, Post Wendy S, Rotter Jerome I, Rich Stephen S, Wilson James G, Ebert Benjamin L, Yu Bing, Ballantyne Christie M, Coresh Josef, Sankaran Vijay G, Bick Alexander G, Jaiswal Siddhartha, Gerszten Robert E, Libby Peter, Gupta Rajat M, Natarajan Pradeep
Abstract excerpt
Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 participants (3881 with CHIP) from TOPMed and UK Biobank (UKB) with...
Topics
Join the communities discussing this publication.