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Article

Nesprin1 Deficiency Is Associated with Poor Prognosis of Renal Cell Carcinoma and Resistance to Sunitinib Treatment.

Oncology - 1 Jan 2024

Fukushima Takafumi, Kobatake Kohei, Miura Kento, Takemoto Kenshiro, Yamanaka Ryoken, Tasaka Ryo, Kohada Yuki, Miyamoto Shunsuke, Sekino Yohei, Kitano Hiroyuki, Goto Keisuke, Ikeda Kenichiro, Goriki Akihiro, Hieda Keisuke, Kaminuma Osamu, Hinata Nobuyuki

Abstract excerpt

INTRODUCTION: Nuclear envelope spectrin repeat protein (Nesprin) 1 encoded by SYNE1, crucially regulates the morphology and functions of the cell. Mutations in the SYNE1 gene are associated with various diseases; however, their significance in renal cell carcinoma (RCC) remains unknown. In this study, we have investigated the association of SYNE1/Nesprin1 with the progression and prognosis of clear cell RCC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38442705
DOI: 10.1159/000536539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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