Article
Nesprin-1 impact on tumorigenic cell phenotypes.
Molecular biology reports - 1 Feb 2020
Sur-Erdem Ilknur, Hussain Muhammed Sajid, Asif Maria, Pınarbası Nareg, Aksu Ali Cenk, Noegel Angelika A
Abstract excerpt
The largest protein of the nuclear envelope (NE) is Nesprin-1 which forms a network along the NE interacting with actin, Emerin, Lamin, and SUN proteins. Mutations in the SYNE1 gene and reduction in Nesprin-1 protein levels have been reported to correlate with several age related diseases and cancer. In the present study, we tested whether Nesprin-1 overexpression can reverse the malignant phenotype of Huh7...
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