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Article

The S-S bridge mutation between the A2 and A4 loops (T416C-I432C) of Cel7A of Aspergillus fumigatus enhances catalytic activity and thermostability.

Applied and environmental microbiology - 17 Apr 2024

Dodda Subba Reddy, Hossain Musaddique, Mondal Sudipa, Das Shalini, Khator Jain Sneha, Aikat Kaustav, Mukhopadhyay Sudit S

Abstract excerpt

Disulfide bonds are important for maintaining the structural conformation and stability of the protein. The introduction of the disulfide bond is a promising strategy to increase the thermostability of the protein. In this report, cysteine residues are introduced to form disulfide bonds in the Glycoside Hydrolase family GH 7 cellobiohydrolase (GH7 CBHs) or Cel7A of Aspergillus fumigatus. Disulfide by Design 2.0...

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PMID: 38440989
DOI: 10.1128/aem.02329-23
PMCID: PMC11022540

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