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Article

Carboxyl-peptide plane stacking is important for stabilization of buried E305 of Trichoderma reesei Cel5A.

Journal of chemical information and modeling - 26 Jan 2015

He Chunyan, Chen Jingfei, An Liaoyuan, Wang Yefei, Shu Zhiyu, Yao Lishan

Abstract excerpt

Hydrogen bonds or salt bridges are usually formed to stabilize the buried ionizable residues. However, such interactions do not exist for two buried residues D271 and E305 of Trichoderma reesei Cel5A, an endoglucanase. Mutating D271 to alanine or leucine improves the enzyme thermostability quantified by the temperature T50 due to the elimination of the desolvation penalty of the aspartic acid. However, the same...

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Identifiers

PMID: 25569819
DOI: 10.1021/ci500610m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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