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Article

Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

Nature genetics - 1 Dec 2016

Eppinga Ruben N, Hagemeijer Yanick, Burgess Stephen, Hinds David A, Stefansson Kari, Gudbjartsson Daniel F, van Veldhuisen Dirk J, Munroe Patricia B, Verweij Niek, van der Harst Pim

Abstract excerpt

Resting heart rate is a heritable trait correlated with life span. Little is known about the genetic contribution to resting heart rate and its relationship with mortality. We performed a genome-wide association discovery and replication analysis starting with 19.9 million genetic variants and studying up to 265,046 individuals to identify 64 loci associated with resting heart rate (P < 5 × 10-8); 46 of these...

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Identifiers

PMID: 27798624
DOI: 10.1038/ng.3708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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