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Multi-trait GWAS reveals divergent local and polygenic architecture of cardiovascular traits across African and European ancestries in the UK Biobank.

Communications biology - 2 May 2026

Sinkala Musalula, Elsheikh Samar, Mbiyavanga Mamana, Cullinan Joshua, Mulder Nicola

Abstract excerpt

The genetic architecture of cardiovascular traits is poorly characterised in non-European populations, limiting our understanding of disease aetiology and contributing to health disparities. Here, we analyse the genetic architecture of four cardiovascular traits (systolic and diastolic blood pressure, pulse rate, and maximum heart rate) using multi-trait analysis of genome-wide association studies and local...

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PMID: 42069820
DOI: 10.1038/s42003-026-09977-1
PMCID: PMC13342579

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