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Article

Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping.

Science advances - 1 Mar 2024

Teixeira Samantha K, Pontes Roberto, Zuleta Luiz Fernando G, Wang Jianhui, Xu Darui, Hildebrand Sara, Russell Jamie, Zhan Xiaoming, Choi Mihwa, Tang Miao, Li Xiaohong, Ludwig Sara, Beutler Bruce, Krieger Jose E

Abstract excerpt

We used N-ethyl-N-nitrosurea-induced germline mutagenesis combined with automated meiotic mapping to identify specific systolic blood pressure (SBP) and heart rate (HR) determinant loci. We analyzed 43,627 third-generation (G3) mice from 841 pedigrees to assess the effects of 45,378 variant alleles within 15,760 genes, in both heterozygous and homozygous states. We comprehensively tested 23% of all...

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Identifiers

PMID: 38427739
DOI: 10.1126/sciadv.adj9797
PMCID: PMC10906923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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