Article
Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability.
Genetics, selection, evolution : GSE - 29 Feb 2024
Ben Braiek Maxime, Moreno-Romieux Carole, André Céline, Astruc Jean-Michel, Bardou Philippe, Bordes Arnaud, Debat Frédéric, Fidelle Francis, Granado-Tajada Itsasne, Hozé Chris, Plisson-Petit Florence, Rivemale François, Sarry Julien, Tadi Némuel, Woloszyn Florent, Fabre Stéphane
Abstract excerpt
BACKGROUND: Recessive deleterious variants are known to segregate in livestock populations, as in humans, and some may be lethal in the homozygous state. RESULTS: We used phased 50 k single nucleotide polymorphism (SNP) genotypes and pedigree data to scan the genome of 6845 Manech Tête Rousse dairy sheep to search for deficiency in homozygous haplotypes (DHH). Five Manech Tête Rousse deficient homozygous...
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