Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel nonsense mutation in the DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep.

PloS one - 1 Jan 2011

Zhao Xia, Dittmer Keren E, Blair Hugh T, Thompson Keith G, Rothschild Max F, Garrick Dorian J

Abstract excerpt

Inherited rickets of Corriedale sheep is characterized by decreased growth rate, thoracic lordosis and angular limb deformities. Previous outcross and backcross studies implicate inheritance as a simple autosomal recessive disorder. A genome wide association study was conducted using the Illumina OvineSNP50 BeadChip on 20 related sheep comprising 17 affected and 3 carriers. A homozygous region of 125 consecutive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Nonsense
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Genes, Recessive

Share to Genomics

Share to Homozygote

Share to Rickets

Source

Open in PubMed Open full text

Identifiers

PMID: 21747952
DOI: 10.1371/journal.pone.0021739
PMCID: PMC3128599

Genes

DMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel nonsense mutation in the DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep.PMID 21747952Read ↗

In a shake of a lamb's tail: using genomics to unravel a cause of chondrodysplasia in Texel sheep.Semantic proximity Read ↗

Brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS) in Merino sheep maps to a 1.1-megabase region on ovine chromosome OAR2.Semantic proximity Read ↗

Identification of a novel dentin matrix protein-1 (DMP-1) mutation and dental anomalies in a kindred with autosomal recessive hypophosphatemia.Semantic proximity Read ↗

The First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1.Semantic proximity Read ↗

A genome-wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep.Semantic proximity Read ↗

Exome sequencing reveals a mutation in DMP1 in a family with familial sclerosing bone dysplasia.Semantic proximity Read ↗

Whole-genome resequencing of Ujumqin sheep to investigate the determinants of the multi-vertebral trait.Semantic proximity Read ↗

[Autosomal recessive hypophosphatemic rickets/osteomalacia caused by a novel mutation in the DMP1 gene: a case report and literature review].Semantic proximity Read ↗

Genetic testing for phenotype-causing variants in sheep and goats.Semantic proximity Read ↗

Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes.Semantic proximity Read ↗

First report in Argentina of a pathogenic DMP1 variant associated with autosomal recessive hypophosphatemic rickets.Semantic proximity Read ↗

Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.