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Article

Enterohemorrhagic Escherichia coli specific enterohemolysin induced IL-1β in human macrophages and EHEC-induced IL-1β required activation of NLRP3 inflammasome.

PloS one - 1 Jan 2012

Zhang Xiaoai, Cheng Yuli, Xiong Yanwen, Ye Changyun, Zheng Han, Sun Hui, Zhao Hongqing, Ren Zhihong, Xu Jianguo

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major foodborne pathogen causing hemorrhagic colitis and hemolytic-uremic syndrome. The role of EHEC O157:H7-enterohemolysin (Ehx) in the pathogenesis of infections remains poorly defined. In this study, we used gene deletion and complement m...

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Identifiers

PMID: 23209696
DOI: 10.1371/journal.pone.0050288
PMCID: PMC3507778

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23209696-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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