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Article

Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease

27 Oct 2021

Abstract excerpt

The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation. The activation of caspases results in the maturation of pro-inflammatory cytokines IL-1β and IL-18 or pyroptosis. Inflammasome dysfunction is associated with the...

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PMID: 34705319
DOI: 10.15252/emmm.202013452

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