Article
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Nature medicine - 1 May 2016
Burridge Paul W, Li Yong Fuga, Matsa Elena, Wu Haodi, Ong Sang-Ging, Sharma Arun, Holmström Alexandra, Chang Alex C, Coronado Michael J, Ebert Antje D, Knowles Joshua W, Telli Melinda L, Witteles Ronald M, Blau Helen M, Bernstein Daniel, Altman Russ B, Wu Joseph C
Abstract excerpt
Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of malignancies, but it causes a dose-related cardiotoxicity that can lead to heart failure in a subset of patients. At present, it is not possible to predict which patients will be affected by doxorubicin-induced cardiotoxicity (DIC). Here we demonstrate that patient-specific human induced pluripotent stem cell-derived...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.