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S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens

26 Feb 2024

Abstract excerpt

Oxidative (or respiratory) burst confers host defense against pathogens by generating reactive species, including reactive nitrogen species (RNS). The microbial infection-induced excessive RNS damages many biological molecules via S-nitrosothiol (SNO) accumulation. However, the mechanism by which the host enables innate immunity activation during oxidative burst remains largely unknown. Here, we demonstrate that...

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PMID: 38409248
DOI: 10.1038/s41467-024-46212-z

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