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Article

Thrombospondin-1, BIM and CFH polymorphisms and response to anti-VEGF treatment in neovascular age- related macular degeneration patients.

PloS one - 1 Jan 2024

Sorenson Christine M, Gurel Zafer, Song Yong-Seok, Peterson Kyle D, Blodi Barbara A, Sheibani Nader

Abstract excerpt

Age-related macular degeneration (AMD) is a vision threatening disease in older adults. Anti-VEGF treatment is effective for the majority of neovascular AMD (nAMD) patients, although approximately 30% of nAMD patients have an incomplete response for unknown reasons. Here we assessed the contribution of single nucleotide polymorphisms (SNPs) in key angioinflammatory regulatory genes in nAMD patients with an...

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Source

Open in PubMed Open full text

Identifiers

PMID: 38408093
DOI: 10.1371/journal.pone.0297135
PMCID: PMC10896504

Genes

CFH
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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