Article
HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype.
Viruses - 26 Jan 2024
Zhitkevich Alla, Bayurova Ekaterina, Avdoshina Darya, Zakirova Natalia, Frolova Galina, Chowdhury Sona, Ivanov Alexander, Gordeychuk Ilya, Palefsky Joel M, Isaguliants Maria
Abstract excerpt
The high incidence of epithelial malignancies in HIV-1 infected individuals is associated with co-infection with oncogenic viruses, such as high-risk human papillomaviruses (HR HPVs), mostly HPV16. The molecular mechanisms underlying the HIV-1-associated increase in epithelial malignancies are not fully understood. A collaboration between HIV-1 and HR HPVs in the malignant transformation of epithelial cells has...
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