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APOE-ε4 Alleles Modify the Decline of MMSE Scores Associated With Time-Dependent PM2.5 Exposure: Findings From a Community-Based Longitudinal Cohort Study.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Sept 2024

Hsiao Po-Jen, Wu Chih-Da, Wong Pei-Yi, Chung Mu-Chi, Yang Yu-Wan, Wu Laing-You, Hsiao Kai-Yu, Chung Chi-Jung

Abstract excerpt

OBJECTIVE: Limited research has explored the long-term effect of reduced PM2.5 exposure on cognitive function. This study aimed to investigate the effects of time-dependent PM2.5 exposure and the interactions of PM2.5 and aging on declines in Mini-Mental State Examination (MMSE) scores, in carriers and non-carriers of the APOE-ε4 allele. METHODS: Participants aged over 60 were recruited for this cohort study,...

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Identifiers

PMID: 38228451
DOI: 10.1016/j.jagp.2023.12.021

Genes

APOE

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