Fibrocyte and T cell interactions promote disease pathogenesis in rheumatoid arthritis.

doi:10.1016/j.jaut.2016.02.008

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Article

Fibrocyte and T cell interactions promote disease pathogenesis in rheumatoid arthritis.

Journal of autoimmunity - 1 May 2016

Galligan Carole L, Keystone Edward C, Fish Eleanor N

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic autoimmune disease. We previously identified a circulating cell population, fibrocytes, which is activated early in disease. As RA is characterized by the formation of autoantibodies and autoreactive T cells, which often precede symptom onset, the objective of these studies was to characterize fibrocyte activation in the context of T cell activation. Multidimensional flow...

Topics

Adult
Animals
Arthritis, Rheumatoid
Biomarkers
Case-Control Studies
Cell Communication
Connective Tissue Cells
Cytokines
Female
Humans
Immunophenotyping
Lymphocyte Activation
Lymphocyte Count
Male
Mice
Middle Aged
Phenotype
T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 26948996
DOI: 10.1016/j.jaut.2016.02.008

Genes

FOXP3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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