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Article

Single-cell analysis identified POSTN+ cells associated with the aggressive phenotype and risk of esophageal squamous cell carcinoma.

HGG advances - 11 Apr 2024

Tan Yuqian, Song Lina, Ma Jialing, Pan Miaoxin, Niu Siyuan, Yue Xinying, Li Yueping, Gu Linglong, Liu Shasha, Chang Jiang

Abstract excerpt

Tumors are intricate and heterogeneous systems characterized by mosaic cancer cell populations with diverse expression profiles. Leveraging single-cell technologies, we employed the Scissor algorithm to delineate an epithelial subpopulation associated with the aggressive phenotype in esophageal squamous cell carcinoma (ESCC). This identified subpopulation exhibited elevated expression of genes involved in...

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Share to Carcinoma, Squamous Cell
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

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Share to Phosphatidylinositol 3-Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 38369754
DOI: 10.1016/j.xhgg.2024.100278
PMCID: PMC10924139

Genes

POSTN
CAV1
COL3A1
COL6A1
PRRX1
TAGLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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