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Article

RNAi screens identify CHD4 as an essential gene in breast cancer growth.

Oncotarget - 6 Dec 2016

D'Alesio Carolina, Punzi Simona, Cicalese Angelo, Fornasari Lorenzo, Furia Laura, Riva Laura, Carugo Alessandro, Curigliano Giuseppe, Criscitiello Carmen, Pruneri Giancarlo, Pelicci Pier Giuseppe, Faretta Mario, Bossi Daniela, Lanfrancone Luisa

Abstract excerpt

Epigenetic regulation plays an essential role in tumor development and epigenetic modifiers are considered optimal potential druggable candidates. In order to identify new breast cancer vulnerabilities and improve therapeutic chances for patients, we performed in vivo and in vitro shRNA screens in a human breast cancer cell model (MCF10DCIS.com cell line) using epigenetic libraries. Among the genes identified in...

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Identifiers

PMID: 27779108
DOI: 10.18632/oncotarget.12646
PMCID: PMC5348363

Genes

CHD4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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