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Article

Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer

8 May 2012

Abstract excerpt

INTRODUCTION: The chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a tumor suppressor in a mouse model. The CHD5 locus at 1p36 is deleted, and its mutation has been detected in breast cancer. We, therefore, evaluated whether CHD5 plays a role in human breast cancer. METHODS: We screened mutations in 55 tumors, determined promoter methylation in 39 tumors, measured RNA expression...

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PMID: 22569290
DOI: 10.1186/bcr3182

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