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Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies

17 Feb 2024

Abstract excerpt

Abstract Purpose We hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe striatal dopamine deficiency in four-repeat (4R) tauopathies. Therefore, we correlated [18F]PI-2620 tau-positron-emission-tomography (PET) imaging with [123I]-Ioflupane single-photon-emission-computed tomography (SPECT) for dopamine transporter (DaT)...

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PMID: 38366196
DOI: 10.1007/s00259-024-06637-6

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