Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Contribution and Clinical Implication of Cancer-Associated Fibroblasts in Glioblastoma

7 Dec 2023

Abstract excerpt

PURPOSE: The abundance and biological contribution of cancer-associated fibroblasts (CAF) in glioblastoma (GBM) are poorly understood. Here, we aim to uncover its molecular signature, cellular roles, and potential tumorigenesis implications. EXPERIMENTAL DESIGN: We first applied single-cell RNA sequencing (RNA-seq) and bioinformatics analysis to identify and characterize stromal cells with CAF transcriptomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Glioma Diagnosis and Treatment
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38060213
DOI: 10.1158/1078-0432.ccr-23-0493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Contribution and Clinical Implication of Cancer-Associated Fibroblasts in GlioblastomaPMID 38060213Read ↗

Functional Contribution of Cancer-Associated Fibroblasts in GlioblastomaSemantic proximity Read ↗

Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effectsSemantic proximity Read ↗

Pericyte-Derived Cancer-Associated Fibroblasts Correlate with Poor Survival and Are Enriched After Chemoradiotherapy in GlioblastomaSemantic proximity Read ↗

Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysisSemantic proximity Read ↗

Cancer-associated fibroblast–secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomasSemantic proximity Read ↗

Glioblastoma induces CAF-like astrocyte activation via the AKT/mTOR–SERPINH1/COL5A1 axisSemantic proximity Read ↗

Single-cell sequencing reveals the landscape of the human brain metastatic microenvironmentSemantic proximity Read ↗

A prognostic matrix code defines functional glioblastoma phenotypes and nichesSemantic proximity Read ↗

Elucidating the Predominant Role of AEBP1 in Different Types of Cancers with a Focus on Glioblastoma Progression – A ReviewSemantic proximity Read ↗

Single‐cell RNA sequencing to explore cancer‐associated fibroblasts heterogeneity: “Single” vision for “heterogeneous” environmentSemantic proximity Read ↗

Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in GlioblastomaSemantic proximity Read ↗

A multi-omics atlas of CAF subtypes reveals apCAF–M2 macrophage interactions driving immune resistance in gliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.