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A multi-omics atlas of CAF subtypes reveals apCAF–M2 macrophage interactions driving immune resistance in glioma

11 Aug 2025

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are a critical component of the glioma microenvi-ronment and play essential roles in tumor progression and resistance to immunotherapy. To comprehensively characterize CAF heterogeneity and their interactions with immune cells, we conducted an integrative multi-omics analysis incorporating single-cell and bulk RNA sequencing, spatial transcriptomics, and multiplex...

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PMID: 40788933
DOI: 10.1371/journal.pone.0329801

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