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RhoB expression associated with chemotherapy response and prognosis in colorectal cancer

15 Feb 2024

Abstract excerpt

PURPOSE: To examine the role of RhoB expression in relation to chemotherapy response, clinical outcomes and associated signaling pathways in colorectal cancer patients. MATERIALS AND METHODS: The study included 5 colon cancer cell lines, zebrafish embryos and 260 colorectal cancer patients treated with 5-fluorouracil (5-FU) and oxaliplatin (OXL). The methods consisted of CRISPR/Cas9, reactive oxygen species...

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PMID: 38355625
DOI: 10.1186/s12935-024-03236-1

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