Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment.

doi:10.1158/1535-7163.MCT-10-0137

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Article

Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment.

Molecular cancer therapeutics - 1 Dec 2010

Ragusa Marco, Majorana Alessandra, Statello Luisa, Maugeri Marco, Salito Loredana, Barbagallo Davide, Guglielmino Maria Rosa, Duro Laura R, Angelica Rosario, Caltabiano Rosario, Biondi Antonio, Di Vita Maria, Privitera Giuseppe, Scalia Marina, Cappellani Alessandro, Vasquez Enrico, Lanzafame Salvatore, Basile Francesco, Di Pietro Cinzia, Purrello Michele

Abstract excerpt

The relationship between therapeutic response and modifications of microRNA (miRNA) transcriptome in colorectal cancer (CRC) remains unknown. We investigated this issue by profiling the expression of 667 miRNAs in 2 human CRC cell lines, one sensitive and the other resistant to cetuximab (Caco-2 and HCT-116, respectively), through TaqMan real-time PCR. Caco-2 and HCT-116 expressed different sets of miRNAs after...

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PMID: 20881268
DOI: 10.1158/1535-7163.MCT-10-0137

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