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[GBA mutations and Parkinson's disease].

Sheng li xue bao : [Acta physiologica Sinica] - 25 Jun 2018

Wang Dong-Xia, Xie Jun-Xia, Song Ning

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra and the intraneuronal Lewy bodies in this area. Genetic mutations in PD pathogenesis have been explored and better understood in recent years. GBA variants are now considered to be the single largest risk factor for PD. Gaucher disease (GD) is a lysosomal storage...

Topics

Cognitive Dysfunction
Dopaminergic Neurons
Gaucher Disease
Glucosylceramidase
Humans
Mutation
Parkinson Disease
Parkinsonian Disorders
Risk Factors
Substantia Nigra
alpha-Synuclein

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PMID: 29926071

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