Article
Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2024
Adams Cameron, Manouchehrinia Ali, Quach Hong L, Quach Diana L, Olsson Tomas, Kockum Ingrid, Schaefer Catherine, Ponting Chris P, Alfredsson Lars, Barcellos Lisa F
Abstract excerpt
Although evidence exists for a causal association between 25-hydroxyvitamin D (25(OH)D) serum levels, and multiple sclerosis (MS), the role of variation in vitamin D receptor (VDR) binding in MS is unknown. Here, we leveraged previously identified variants associated with allele imbalance in VDR binding (VDR-binding variant; VDR-BV) in ChIP-exo data from calcitriol-stimulated lymphoblastoid cell lines and 25(OH)D...
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