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Article

Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes

11 Feb 2013

Abstract excerpt

BACKGROUND: Vitamin D is a liposoluble vitamin essential for calcium metabolism. The ligand-bound vitamin D receptor (VDR), heterodimerized with retinoid X receptor, interacts with vitamin D response elements (VDREs) to regulate gene expression. Vitamin D deficiency due to insufficient sunlight exposure confers an increased risk for multiple sclerosis (MS). OBJECTIVE: To study a protective role of vitamin D in...

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PMID: 23401126
DOI: 10.1177/1352458512471873

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