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Article

Intragenic Rearrangement Burden Associates with Immune Cell Infiltration and Response to Immune Checkpoint Blockade in Cancer.

Cancer immunology research - 4 Mar 2024

Zhang Han, Lee Sanghoon, Muthakana Renee R, Lu Binfeng, Boone David N, Lee Daniel, Wang Xiao-Song

Abstract excerpt

Immune checkpoint blockade (ICB) can induce durable cancer remission. However, only a small subset of patients gains benefits. While tumor mutation burden (TMB) differentiates responders from nonresponders in some cases, it is a weak predictor in tumor types with low mutation rates. Thus, there is an unmet need to discover a new class of genetic aberrations that predict ICB responses in these tumor types. Here,...

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Identifiers

PMID: 38345376
DOI: 10.1158/2326-6066.CIR-22-0637
PMCID: PMC11107381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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