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Article

The Macrophage Landscape Across the Lifespan of a Human Cardiac Allograft

12 Feb 2024

Abstract excerpt

BACKGROUND: Much of our knowledge of organ rejection after transplantation is derived from rodent models. METHODS: We used single-nucleus RNA sequencing to investigate the inflammatory myocardial microenvironment in human pediatric cardiac allografts at different stages after transplantation. We distinguished donor- from recipient-derived cells using naturally occurring genetic variants embedded in single-nucleus...

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PMID: 38344825
DOI: 10.1161/circulationaha.123.065294

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