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Article

Indirect influence of microRNA-146a on the association of IL-6 and TNF-α genetic polymorphisms with the increased risk of hip osteoarthritis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jul 2024

Tudor Karlo, Baranasic Jurica, Knezevic Jelena, Serer Vicevic Marta, Sutic Maja, Dembic Zlatko, Jotanovic Zdravko

Abstract excerpt

Primary osteoarthritis (POA) is a complex hereditary disease that involves the interplay between genetics and epigenetics. MicroRNA molecules play important roles in epigenetic mechanisms. MicroRNA-146a (miR-146a) is a negative regulator of the immune response in osteoarthritis (OA). So, variations in the miR-146a gene could affect OA risk. The aim of this study was to investigate the relationships between single...

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PMID: 38341771
DOI: 10.1002/jor.25804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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