Article
Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis.
Archivum immunologiae et therapiae experimentalis - 1 Dec 2016
Bogunia-Kubik Katarzyna, Wysoczańska Barbara, Piątek Dagmara, Iwaszko Milena, Ciechomska Marzena, Świerkot Jerzy
Abstract excerpt
MicroRNA-146a (miR-146a) has been shown to play an important role in the regulation of inflammatory innate immune responses, and found to be differentially expressed in rheumatoid arthritis (RA). Through NF-κB pathway, this molecule is able to stimulate the release of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-17. It has been also suggested that single-nucleotide polymorphisms (SNPs) in miRNA...
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