Genomic surveillance of Clostridioides difficile transmission and virulence in a healthcare setting

Abstract excerpt

ABSTRACT Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, despite the widespread implementation of contact precautions for patients with CDI. Here, we investigate strain contamination in a hospital setting and the genomic determinants of disease outcomes. Across two wards over 6 months, we selectively cultured C. difficile from patients ( n = 384) and their...