A Genomic Analysis of Community-Associated C. difficile Infection Demonstrates Integration With National and International Strain Clusters and Limited Direct Transmission.

Abstract excerpt

BACKGROUND: Clostridioides difficile is a life-threatening gastrointestinal infection. Once predominantly associated with healthcare exposure, community-associated C. difficile infections (CA-CDI) now account for more than half of U.S. cases, and sources and transmission dynamics remain poorly defined. METHODS: We sequenced 454 C. difficile isolates, collected over a 6-month period, from CDI cases through labs...

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