Article
A Genomic Analysis of Community-Associated C. difficile Infection Demonstrates Integration With National and International Strain Clusters and Limited Direct Transmission.
The Journal of infectious diseases - 16 Jun 2026
Pecora Nicole D, Dumyati Ghinwa, Holt Kathleen, Taffner Samantha, Tesini Brenda L
Abstract excerpt
BACKGROUND: Clostridioides difficile is a life-threatening gastrointestinal infection. Once predominantly associated with healthcare exposure, community-associated C. difficile infections (CA-CDI) now account for more than half of U.S. cases, and sources and transmission dynamics remain poorly defined. METHODS: We sequenced 454 C. difficile isolates, collected over a 6-month period, from CDI cases through labs...
Topics
- Clostridioides difficile
- Humans
- Community-Acquired Infections
- Clostridium Infections
- Multilocus Sequence Typing
- Genome, Bacterial
- Polymorphism, Single Nucleotide
- Cluster Analysis
- Molecular Epidemiology
- Cross Infection
- Genetic Variation
- Genomics
- New York