Article
Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Dec 2020
Pérez-Ruiz Elisabeth, Melero Ignacio, Kopecka Joanna, Sarmento-Ribeiro Ana Bela, García-Aranda Marilina, De Las Rivas Javier
Abstract excerpt
Cancer is one of the main public health problems in the world. Systemic therapies such as chemotherapy and more recently target therapies as well as immunotherapy have improved the prognosis of this large group of complex malignant diseases. However, the frequent emergence of multidrug resistance (MDR) mechanisms is one of the major impediments towards curative treatment of cancer. While several mechanisms of...
Topics
- Animals
- B7-H1 Antigen
- Biomarkers, Tumor
- CD8-Positive T-Lymphocytes
- CTLA-4 Antigen
- Cell Line, Tumor
- Disease Models, Animal
- Humans
- Immune Checkpoint Inhibitors
- Lymphocytes, Tumor-Infiltrating