Article
Gene-based association tests in family samples using GWAS summary statistics.
Genetic epidemiology - 1 Apr 2024
Wang Peng, Xu Xiao, Li Ming, Lou Xiang-Yang, Xu Siqi, Wu Baolin, Gao Guimin, Yin Ping, Liu Nianjun
Abstract excerpt
Genome-wide association studies (GWAS) have led to rapid growth in detecting genetic variants associated with various phenotypes. Owing to a great number of publicly accessible GWAS summary statistics, and the difficulty in obtaining individual-level genotype data, many existing gene-based association tests have been adapted to require only GWAS summary statistics rather than individual-level data. However, these...
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